Juvenile systemic lupus erythematous in Iranian children

نویسندگان

  • Fatemeh Tahghighi
  • Vahid Ziaee
  • Mohamad-Hassan Moradinejad
  • Fatemeh Fereshteh Mehregan
چکیده

Results A total of 59 patients, 49 (89%) were female and10 (16.9%) male. The female to male ratio was 4.9:1. The mean age of onset was 10.5 years (range 2-16). The mean duration of disease from diagnosis was 2 years (range7 months-5 years). The most common of constitutional sign was fatigue (76.3%) and the other signs were fever (32.2%), Nocturnal pain (20.3%), Mood disorder (20.03%), and Weight loss (22%). The most common manifestation of JSLE were as follows: 48 patients (81.35%) had mucocutaneous involvement, 46 patients (77.9%) had musculoskeletal involvement, 25 children (42.37%) suffered from renal disease, hematological abnormalities were detected in 19 patients (32.2%), 10 patients (16.94%) had cardiovascular disease, 33 patients (55.93%) presented nervous system involvement, 12 patients (20.33%) had pulmonary disease, and 13 patients (22.03) experienced infection complications. During the follow up period(3years) two patients died, one from renal failure, one from infections. Conclusion A high index of suspicion must be preserved for the diagnosis of SLE in adolescent children, particularly girls. Juvenile systemic lupus erythematous (JSLE) is a critical multi-system organ disease. JSLE still has a significant mortality rate high, although it has a high remission rate with early diagnosis and treatment.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Cutaneous Manifestations of Systemic Lupus Erythematosus in Iranian Children

Systemic lupus erythematous (SLE) is an autoimmune process in which cutaneous lesions occur in majority of patients. This study was conducted to determine the pattern and prevalence of such lesions in SLE in Iranian children infected with SLE. Forty-eight patients, age between 3-16 yrs and male to female ratio of 7/1 were examined for the presence of cutaneous manifestations of SLE. The most co...

متن کامل

Association of HLA-DRB1 Alleles in Juvenile-onset Systemic Lupus Erythematosus (SLE) in Iranian Children

Introduction Systemic Lupus Erythematosus (SLE) is a complex autoimmune and inflammatory disease. Many studies show HLA alleles can be associated with SLE. The aim of this study was to determine the association of HLA-DRB1 alleles with juvenile- onset in Iranian children. Materials and Methods At a case – control study, 31 children with systemic lupus erythematosus (case group) who referred to ...

متن کامل

Juvenile systemic lupus erythematosus: review of clinical features and management.

879 VOLUME 48__NOVEMBER 17, 2011 Juvenile systemic lupus erythematous (SLE) is a multisystem autoimmune disorder that is characterized by widespread immune dysregulation, formation of autoantibodies and immune complexes, resulting in inflammation and potential damage to a variety of organs. It is not uncommon for children to present with non-specific symptoms, and little else, and be treated fo...

متن کامل

Clinical and Laboratory Investigation of Children with Systemic Lupus Erythematosus (SLE) Referring to Lupus Clinic of Dr. Sheikh Hospital, Mashhad, Iran

Background: Systemic lupus erythematous (SLE) is a multisystemic and autoimmune inflammatory disease characterized by production of autoantibodies against different cellular components. We aimed to investigate children with SLE in terms of clinical symptoms and laboratory findings who referred to Lupus clinic.Materials and Methods: In this cross-sectional study, 36 children with SLE refer...

متن کامل

Comparative of irrational beliefs and diseases anxiety disorders in women with systemic lupus erythematous and healthy women

The aim of this study was to compare irrational beliefs and anxiety disorder (self-morbidity) in women with and without systemic lupus erythematosus. This was a descriptive causal-comparative study. The statistical population of the study included all female patients with systemic lupus erythematosus in Kermanshah in 2018. By random sampling method, 50 women with lupus and 50 non-lupus were sel...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 12  شماره 

صفحات  -

تاریخ انتشار 2014